Ranexa (generic name: ranolazine) is a medication used to treat chronic angina (chest pain). Here’s what you need to know about Ranexa 375mg:

Active Ingredient:

• Ranolazine: Ranolazine is an anti-anginal medication that helps improve blood flow to help the heart work more efficiently.

Dosage Strength:

• Ranexa 375mg: This dosage form is less commonly referenced in prescribing information and is typically used as an initial starting dose.

Uses:

• Chronic Angina: Ranexa is prescribed for the treatment of chronic angina, typically used in combination with other heart medications to help reduce the frequency of angina episodes.

Dosage and Administration:

• Starting Dose: The typical starting dose is 500mg twice daily, but for some patients, a lower starting dose like 375mg twice daily may be recommended based on individual needs and tolerance.
• Titration: The dose may be adjusted based on clinical response and tolerability, with the usual maintenance dose being 500mg to 1000mg twice daily.
• Administration: Ranexa should be taken twice daily, with or without food. The tablets should be swallowed whole and not crushed, broken, or chewed.

Precautions:

• Medical Conditions: Inform your doctor if you have a history of liver or kidney disease.
• Drug Interactions: Ranexa can interact with other medications, including certain antibiotics, antifungals, and medications for heart rhythm disorders. Make sure your doctor is aware of all the medications you are taking.

Side Effects:

• Common Side Effects: Dizziness, headache, constipation, and nausea.
• Serious Side Effects: Palpitations, fainting, and severe dizziness. Report these to your healthcare provider immediately.

Contraindications:

• Liver Cirrhosis: Ranexa is contraindicated in patients with liver cirrhosis.
• Drug Interactions: Avoid using Ranexa with strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) and certain other medications that prolong the QT interval.

Storage:

• Storage Conditions: Store Ranexa at room temperature, away from moisture and heat, and out of reach of children.

Important Notes:

• Regular Monitoring: Periodic medical tests (e.g., EKG, blood pressure) may be necessary to monitor your condition and ensure the medication is working properly.
• Lifestyle Changes: In addition to taking Ranexa, following a healthy diet, regular exercise, and avoiding smoking can help manage angina symptoms effectively.